학술논문
The 2001 Veylien Henderson Award of the Society of Toxicology of Canada. Positive and negative transcriptional regulation of cytochromes P450 by polycyclic aromatic hydrocarbons.
Document Type
Article
Source
Subject
*HYDROCARBONS
*CYTOCHROME P-450
*SOMATOTROPIN
*CYTOCHROMES
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Language
ISSN
0008-4212
Abstract
Presents a study that examined the mechanisms by which aromatic hydrocarbons suppress constitutive hepatic cytochromes P450 especially the male-specific rat liver cytochrome P450 2C11 (CYP2C11) which is regulated by pulsatile growth hormone secretion. Involvement of aromatic hydrocarbon receptors (AHR) in the suppression of CYP2C11; Application of studies of protein-DNA interactions and reporter genes driven by the CYP2C15'-flanking region in providing a definitive mechanism for the suppression phenomenon; Possible regulation of the hepatic AHR protein by pituitary factors.