학술논문
The free fatty acid-binding pocket is a conserved hallmark in pathogenic β-coronavirus spike proteins from SARS-CoV to Omicron.
Document Type
Article
Author
Toelzer, Christine; Gupta, Kapil; Yadav, Sathish K. N.; Hodgson, Lorna; Williamson, Maia Kavanagh; Buzas, Dora; Borucu, Ufuk; Powers, Kyle; Stenner, Richard; Vasileiou, Kate; Garzoni, Frederic; Fitzgerald, Daniel; Payré, Christine; Gautam, Gunjan; Lambeau, Gérard; Davidson, Andrew D.; Verkade, Paul; Frank, Martin; Berger, Imre; Schaffitzel, Christiane
Source
Subject
*SARS-CoV-2
*SARS-CoV-2 Omicron variant
*SARS virus
*ANTISENSE DNA
*MERS coronavirus
*FREE fatty acids
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Language
ISSN
2375-2548
Abstract
The article presents a study on the role of free fatty acid (FFA) binding as a hallmark of pathogenic β-coronavirus(CoV) infection and replication, which shows the ability of FFA-based antiviral strategies to overcome COVID-19. Topics discussed include the functional conservation of the trimeric spike FFA-binding pocket in β-CoVs, and molecular dynamic simulations of linoleic acid binding to β-CoV FFA-binding pockets.