학술논문
Synthesis of 2-(1,1-dicyanopropen-2-yl)-6-(2-[18 F]-fluoroethyl)-methylamino-naphthalene ([18 F]FDDNP)
Document Type
Article
Source
Subject
*POLYCYCLIC aromatic hydrocarbons
*POSITRON emission tomography
*MEDICAL imaging systems
*COMPUTER-aided diagnosis
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Language
ISSN
0969-8043
Abstract
Abstract: 2-(1,1-Dicyanopropen-2-yl)-6-(2-[18F]-fluoroethyl)-methylamino-naphthalene ([18F]FDDNP) was synthesized in a single step labeling procedure. The precursor, 2-(1,1-dicyanopropen-2-yl)-6-(2-tosyloxyoethyl)-methylamino-naphthalene, was fluorinated with 18F in acetonitrile. After 15min the reaction mixture was subjected to preparative HPLC purification. The product was isolated from the HPLC eluent with solid-phase extraction, and formulated in an ascorbic acid solution to prevent formation of side products during formulation. Quantitative sticking to tubing and filters was overcome by the addition of polysorbatum-80. This formulation yielded an isotonic, pyrogen-free and sterile solution of [18F]FDDNP. The overall decay-corrected radiochemical yield was 41±11% (n=22). Radiochemical purity was >98% and the specific activity was 102±56GBq/μmol at the end of synthesis. [Copyright &y& Elsevier]