학술논문
A case of recurrent non-small-cell lung carcinoma and paraneoplastic Cushing's syndrome
Document Type
Article
Author
Source
Subject
*LUNG cancer
*CUSHING'S syndrome
*PARANEOPLASTIC syndromes
*ADRENOCORTICOTROPIC hormone
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Language
ISSN
0169-5002
Abstract
Summary: Secretion of ectopic adrenocorticotropic hormone (ACTH) with consequently Cushing''s syndrome is a rare paraneoplastic phenomenon. It has been described in a variety of malignancies, like bronchial carcinoids, small-cell lung carcinoma, thymoma, pancreatic carcinoma and other. In many cases of suspected ectopic ACTH secretion, it is difficult to histologically or cytochemically confirm the diagnosis. We present a 63-year-old woman with a recurrent poorly differentiated squamous cell lung carcinoma with clinical and biochemical features consistent with ectopic Cushing''s syndrome. Immunocytochemical staining confirmed the secretion of ACTH by tumour cells. [Copyright &y& Elsevier]