부산대학교 도서관

Introduction: We previously found that a father's overweight in puberty was associated with nonallergic asthma in his future offspring (Johannessen et al. Fathers' overweight and offspring asthma-an intergenerational perspective. European Resp. Journal 2017, 50:PA2615). Aims: We explored the associations of both fathers and their offsprings personal weight gain during different periods of life with offspring non-allergic asthma. Methods: We analysed questionnaire data from 3018 adult offspring (age 18-50) and their 2153 fathers (age 39-66) participating in the RHINESSA/RHINE generation study in 10 ECRHS centres in North Europe, Spain and Australia. The associations of fathers' and their offsprings weight gain was assessed by 9 body silhouettes (from lean to obese) self-reported for childhood, puberty and adult ages with non-allergic asthma in the offspring. It was analysed using a logistic regression model adjusted for parents and offspring variables, and cluster by family. Results: Non-allergic asthma was related to a weight gain of =2 body silhouettes from 8 years to puberty, both for fathers' weight gain (OR 1.69; 95% CI 1.05-2.72; adjusted for fathers asthma, offspring body mass index, smoking and education) and for their offspring weight gain (1.77 [1.12-2.79], adjusted for parents' education, smoking and asthma, and fathers' weight gain from age 8 to puberty). If the father was overweight at puberty, in addition to having gained weight, non-allergic asthma in the offspring was more than tripled (3.53[1.80-6.94]; weight gain and adjustment as given above). No effect of weight gain from puberty or within adulthood in fathers' or their offspring was observed. Conclusions: Non-allergic asthma was associated with weight gain from childhood to puberty. This was found both for personal weight gain and for having a father who gained weight. [ABSTRACT FROM AUTHOR]