학술논문
Preferential DNA Damage and Poor Repair Determine ras Gene Mutational Hotspot in Human Cancer.
Document Type
Article
Author
Source
Subject
*CANCER
*DNA damage
*RAS oncogenes
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Language
ISSN
0027-8874
Abstract
Examines the tobacco smoke carcinogen-induced DNA damage in human cancer. Use of the UvrABC nuclease incision method in the study; Link between human cancer mutational hotspot at codon 12 of K-ras to preferential DNA damage; Presence of mutations in ras genes in human cancers.