부산대학교 도서관

Heart transplant (HTx) candidates may have elevated pulmonary artery (PA) pressures. In many cases, programs may accept only oversized male donor hearts while declining oversized female donor hearts for HTx candidates with pulmonary hypertension (PH). We reviewed our experience with HTx candidate with PH and male vs female donors.. We assessed 118 candidates on the HTx waitlist 2010-2021 with mean PA pressures > 25mmHg or PA systolic > 40mmHg. Oversized donor hearts defined as predicted heart mass (PHM) >1.10. Subgroup analyses included sex mismatch of oversized donor hearts. Outcomes: 30-day and 1-year survival, 30-day freedom from RV dysfunction, and pulmonary artery pressures at 1-, 3-, and 12-months post-transplant. Recipients of female vs male oversized donor hearts had comparable outcomes in 30-day and 1-year survival and 30-day freedom from RV dysfunction. (Table 1) PA pressures normalized by 1-year post HTx. When donor hearts were separated by age (≥40 years vs <40 years), there was no difference in outcomes (Table 2). There was no interaction between donor sex and age. Female oversized donor hearts by PHM (regardless of donor age) for patients with pulmonary hypertension offer acceptable post-HTx outcomes. [ABSTRACT FROM AUTHOR]