부산대학교 도서관

Objective: This study aimed to investigate the effects of pre-treatment with curcumin nanoparticles compared to conventional curcumin on oxidative stress parameters on isoproterenol(ISO)-induced myocardial infarction (MI) in rats. Methods: Fifty six Wistar-Bratislava white female rats were randomly divided into 8 groups of 7 rats/group. Curcumin (CC) and curcumin nanoparticles (CCNP) were given by gavage in three different doses (100 mg/kg body weight (bw), 150 mg/kg bw, and 200 mg/kg bw) for 15 days. The MI was induced starting from 13th day, using 100 mg/kg of ISO administrated twice, with the second dose at 24h after the initial dose. The blood samples were taken 24 hours after the last dose of ISO, and five oxidative stress parameters were measured: malondialdehyde (MDA), thiol, the indirect assessment of NO synthesis (NOx), total oxidative status (TOS), and total antioxidative capacity (TAC). Results: The induction of MI resulted in an elevation of all oxidative stress markers, up to 2.7 times, and a significant decrease in both thiol and TAC values up to 0.4 times. Doses of 150 and 200 mg/kg bw CC proved more efficient in preventing the increase in MDA and TOS (p≤0.0152). Higher doses of CCNP had same effect on MDA, TOS, and NOx levels (p>0.05). Pretreatment with any CC or CCNP dose prevented the reduction in thiol levels. Higher levels of thiol and TAC were obtained after CCNP administration than after CC (p≤0.0152). Conclusion: Curcumin nanoparticles exert better antioxidative effects compared to conventional curcumin, in case of acute myocardial infarction induced by isoproterenol. [ABSTRACT FROM AUTHOR]