학술논문
Structures of the Heme Acquisition Protein HasA with Iron(III)-5,15-Diphenylporphyrin and Derivatives Thereof as an Artificial Prosthetic Group.
Document Type
Article
Author
Source
Subject
*HEMOPROTEINS
*PORPHYRINS
*CHEMICAL derivatives
*CRYSTAL structure
*PSEUDOMONAS aeruginosa
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Language
ISSN
1433-7851
Abstract
Iron(III)-5,15-diphenylporphyrin and several derivatives were accommodated by HasA, a heme acquisition protein secreted by Pseudomonas aeruginosa, despite possessing bulky substituents at the meso position of the porphyrin. Crystal structure analysis revealed that the two phenyl groups at the meso positions of porphyrin extend outside HasA. It was shown that the growth of P. aeruginosa was inhibited in the presence of HasA coordinating the synthetic porphyrins under iron-limiting conditions, and that the structure of the synthetic porphyrins greatly affects the inhibition efficiency. [ABSTRACT FROM AUTHOR]