학술논문
A Sequentially Copper-Catalyzed Alkyne Carboxylation--Propargylation--Azide Cycloaddition (CuACPAC) Synthesis of 1,2,3-Tri- azolylmethyl Arylpropiolates.
Document Type
Article
Source
Subject
*COPPER catalysts
*ALKYNE synthesis
*CARBOXYLATION
*ALKYLATION
*RING formation (Chemistry)
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Language
ISSN
0936-5214
Abstract
Concatenation of copper-catalyzed alkyne carboxylation-al-kylation and copper-catalyzed alkyne-azide cycloaddition gives a novel sequentially copper-catalyzed alkyne carboxylation-propargylation-azide cycloaddition (CuACPAC) process furnishing 1,2,3-triazolylmethyl arylpropiolates via a consecutive four-component synthesis. The CuACPAC can be expanded to a five-component synthesis of 1,2,3-triazolylmethyl 3-amino arylacrylates by a concluding Michael addition in the same pot. [ABSTRACT FROM AUTHOR]