부산대학교 도서관

The effect of levodopa on muscle activity patterns in Parkinson's disease (PD) patients is currently unclear. The aim of the present study was to compare the spatial distribution pattern of electromyographic activity during sustained isometric contraction in PD patients during on- and off-medication periods using multi-channel surface electromyography (SEMG). Ten female PD patients were recruited for the present study. All patients performed a sustained isometric knee extension at 10% maximum voluntary contraction task for 60 s. To evaluate alterations in the spatial SEMG potential distribution, the coefficient of variation (CV) of force, normalized root mean square (RMS), modified entropy, CV of the RMS, and correlation coefficients were calculated at during contraction task. The off-medication period exhibited more fluctuation during the contraction task than those in the on-medication period. The off-medication period exhibited less change in modified entropy, the CV of RMS, the correlation coefficient and patterns of spatial SEMG distribution. These data demonstrated that the heterogeneity and changes in the activation pattern are smaller in the off-medication period than in those in the on-medication period. These findings might indicate that levodopa enhanced the activation of muscle action potentials during force production. [ABSTRACT FROM AUTHOR]