부산대학교 도서관

Purpose Localization of seizures in frontal lobe epilepsy using the 10–20 system scalp EEG is often challenging because neocortical seizure can spread rapidly, significant muscle artifact, and the suboptimal spatial resolution for seizure generators involving mesial frontal lobe cortex. Our aim in this study was to determine the value of visual interpretation of 76 channel high density EEG (hdEEG) monitoring (10-10 system) in patients with suspected frontal lobe epilepsy, and to evaluate concordance with MRI, subtraction ictal SPECT co-registered to MRI (SISCOM), conventional EEG, and intracranial EEG (iEEG). Methods We performed a retrospective cohort study of 14 consecutive patients who underwent hdEEG monitoring for suspected frontal lobe seizures. The gold standard for localization was considered to be iEEG. Concordance of hdEEG findings with MRI, subtraction ictal SPECT co-registered to MRI (SISCOM), conventional 10–20 EEG, and iEEG as well as correlation of hdEEG localization with surgical outcome were examined. Results hdEEG localization was concordant with iEEG in 12/14 and was superior to conventional EEG 3/14 (p < 0.01) and SISCOM 3/12 (p < 0.01). hdEEG correctly lateralized seizure onset in 14/14 cases, compared to 9/14 ( p = 0.04) cases with conventional EEG. Seven patients underwent surgical resection, of whom five were seizure free. Conclusions hdEEG monitoring should be considered in patients with suspected frontal epilepsy requiring localization of epileptogenic brain. hdEEG may assist in developing a hypothesis for iEEG monitoring and could potentially augment EEG source localization. [ABSTRACT FROM AUTHOR]