학술논문
Mitochondrial targeting of mouse NQO1 and CYP1B1 proteins.
Document Type
Article
Author
Source
Subject
*MITOCHONDRIAL proteins
*GENE targeting
*MESSENGER RNA
*CYTOSOL
*MITOCHONDRIAL membranes
*LABORATORY mice
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Language
ISSN
0006-291X
Abstract
Highlights: [•] Dioxin-treated wild-type, mc1A1, mtt1a1, and 1A1 KO, 1B1 KO and NQO1 KO knockout mice were compared. [•] Analysis included both mRNA and protein quantification of CYP1A1, CYP1B1 and NQO1. [•] NQO1 protein locates to cytosol, ER and mitochondria. [•] CYP1B1 protein (similar to CYP1A1 and CYP1A2 proteins) traffics to mitochondria as well as ER. [•] NQO1 and CYP1B1 targeting to MT or ER membranes is independent of CYP1A1 presence in that membrane. [ABSTRACT FROM AUTHOR]