학술논문
Anti-TNF therapy restores the hypothalamic-pituitary-adrenal axis.
Document Type
Article
Source
Subject
*TUMOR necrosis factors
*RHEUMATOID arthritis treatment
*GLYCOPROTEINS
*GROWTH factors
*MACROPHAGES
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Language
ISSN
0077-8923
Abstract
Tumor necrosis factor (TNF) inhibitors are associated with greater improvements in the symptoms and signs of rheumatoid arthritis (RA) and, more importantly, a lower risk of joint damage. TNF is an important mediator of the alterations in neuroendocrine axes characterizing RA. Long-term therapy with anti-TNF agents sensitizes the pituitary gland and improves adrenal androgen secretion, thus stimulating an alternative form of anti-inflammatory action. [ABSTRACT FROM AUTHOR]