부산대학교 도서관

Objective: We aimed at validating established imaging features of idiopathic intracranial hypertension (IIH) by using stateof-the-art MR imaging together with advanced post-processing techniques and correlated imaging findings to clinicalscores.Methods: Twenty-five IIH patients as well as age-, sex- and body mass index (BMI)-matched controls underwent highresolutionT1w and T2w MR imaging in a 1.5 T scanner, followed by assessment of optic nerve sheaths, pituitary gland,ventricles and Meckel's cave. Imaging findings were correlated with cerebrospinal fluid (CSF) opening pressures and clinicalsymptom scores of visual disturbances (visual field defects or enlarged blind spot), headache, tinnitus (pulsatile and nonpulsatile)and vertigo. CSF as well as ventricle volumes were determined by using an automated MRI volumetry algorithm.Results: So-called 'empty sella' and optic nerve sheath distension were identified as reliable imaging signs in IIH. Posteriorglobe flattening turned out as a highly specific but not very sensitive sign. No abnormalities of the lateral ventricles wereobserved. These morphometric results could be confirmed using MR volumetry (VBM). Clinical symptoms did notcorrelate with an increase in lumbar opening pressure.Conclusions: Our study results indicate that lateral ventricle size is not affected in IIH. In contrast, abnormalities of thepituitary gland and optic nerve sheath were reliable diagnostic signs for IIH. [ABSTRACT FROM AUTHOR]