학술논문
Multispectroscopic investigation of the interaction of BSA and DNA with the anticancer drug, N-(6-ferrocenyl-2-naphthoyl)-gamma-amino butyric acid methyl ester.
Document Type
Article
Author
Source
Subject
*BUTYRATES
*OPTICAL spectroscopy
*ANTINEOPLASTIC agents
*FLUORESCENCE spectroscopy
*DRUG interactions
*DNA
*FATTY acid methyl esters
*
*
*
*
*
*
Language
ISSN
0094-243X
Abstract
The interaction of a drug with DNA and BSA play a great role in studying anti cancer activity and drug transport properties, which can be effectively, investigated using vibrational spectroscopy, UV visible spectroscopy and Fluorescence spectroscopy. The present work reports the structural features of N-(6-ferrocenyl-2-naphthoyl)-gamma-amino butyric acid Methyl ester (FNGABME) based on FTIR and FTRaman spectroscopy. The absorption and fluorescence spectroscopic methods were used to study the efficiency of the interaction of the compound FNGABME with BSA and DNA and also molecular docking were performed computationally to validate the results which shows that the title compound may exhibit inhibitory activity against the cancer cells. [ABSTRACT FROM AUTHOR]