학술논문
Angiopoietin-like proteins stimulate HSPC development through interaction with Notch receptor signaling.
Document Type
Article
Author
Lin, Michelle I.; Price, Emily N.; Boatman, Sonja; Hagedorn, Elliott J.; Trompouki, Eirini; Satishchandran, Sruthi; Carspecken, Charles W.; Uong, Audrey; DiBiase, Anthony; Song Yang; Canver, Matthew C.; Dahlberg, Ann; Zhigang Lu; Cheng Cheng Zhang; Orkin, Stuart H.; Bernstein, Irwin D.; Aster, Jon C.; White, Richard M.; Zon, Leonard I.
Source
Subject
*ANGIOPOIETIN-like proteins
*VASCULAR endothelial growth factors
*HEMATOPOIETIC stem cells
*PROGENITOR cells
*PROTEIN expression
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Language
ISSN
2050-084X
Abstract
The article presents a study showing that angiopoeietin-like protein2 (angptl2) overexpression is enough to expand definitive hematopoietic stem and progenitor cells (HSPCs) in zebrafish embryos. Topics discussed include the need for angptl1 and 2 for definitive hematopoiesis and vascular specification, angptls' genetic interaction with notch, and notch's exertion of cell autonomous effects on hemogenic endothelial cells and HSPCs.