학술논문
MiR-378a-3p enhances adipogenesis by targeting mitogen-activated protein kinase 1.
Document Type
Article
Author
Source
Subject
*ADIPOGENESIS
*MITOGEN-activated protein kinases
*MICRORNA
*GENE targeting
*OBESITY
*BIOCHEMICAL mechanism of action
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Language
ISSN
0006-291X
Abstract
Previous studies showed that miR-378a plays important roles in adipogenesis and obesity; however, the precise mechanisms of action remain unknown. Here, we found that miR-378a-3p expression is up-regulated in adipose tissues of high fat diet-induced obese mice, as well as during the differentiation of 3T3-L1 preadipocytes. Mir-378a-3p induced adipogenesis by targeting mitogen-activated protein kinase 1 (MAPK1). Overexpression of miR-378a-3p or silencing MAPK1 reduced MAPK1 expression and enhanced adipogenesis, whereas blockage of endogenous miR-378a-3p had the opposite effect, suggesting that miR-378a-3p promotes the adipogenesis of 3T3-L1 cells by targeting MAPK1. [ABSTRACT FROM AUTHOR]