학술논문
The Hidden Talents of SPO11
Document Type
Article
Author
Source
Subject
*PROTEIN analysis
*ENZYMATIC analysis
*NUCLEASES
*DOUBLE-stranded RNA
*CHROMOSOME abnormalities
*CELL physiology
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Language
ISSN
1534-5807
Abstract
Meiotic pairing involves a two-step process of DNA double-strand break (DSB)-independent chromosome alignment and precise sequence matching at DSBs. In this issue of Developmental Cell, Boateng et al. (2013) uncover a requirement in the alignment step for SPO11, a nuclease required for DSB formation, independent of its enzymatic activity. [Copyright &y& Elsevier]