학술논문
In vivo mRNA delivery to virus-specific T cells by light-induced ligand exchange of MHC class I antigen-presenting nanoparticles.
Document Type
Article
Author
Source
Subject
*T cells
*T cell receptors
*SARS-CoV-2
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*
Language
ISSN
2375-2548
Abstract
The article offers information about simultaneous delivery of mRNA to multiple populations of antigen (Ag)–specific CD8+ T cells as challenging given the diversity of peptide epitopes and polymorphism of class I major histocompatibility complexes. It mentions that how UV-mediated peptide exchange can be used to rapidly produce APNs for mRNA delivery to multiple populations of Ag-specific T cells in vivo.