학술논문
Identification and characterization of clinical Bacillus spp. isolates phenotypically similar to Bacillus anthracis C.A. Beesley et al. Description of B. anthracis-like clinical isolates.
Document Type
Article
Source
Subject
*BACILLUS anthracis
*ANTHRAX
*FLUORESCENT antibody technique
*MICROBIAL virulence
*PLASMIDS
*PHENOTYPES
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Language
ISSN
0378-1097
Abstract
Bacillus anthracis, the etiological agent of anthrax, is a gram-positive, spore-forming rod, with colonies exhibiting a unique ground-glass appearance, and lacking hemolysis and motility. In addition to these phenotypes, several others traits are characteristic of B. anthracis such as susceptibility to gamma phage, the presence of two virulence plasmids (pX01 and pX02), and specific cell wall and capsular antigens that are commonly detected by direct fluorescent-antibody assays. We report on the identification and characterization of 14 Bacillus megaterium and four Bacillus sp. clinical isolates that are nonhemolytic, nonmotile, and produce a capsule antigenically similar to B. anthracis. This work furthers our understanding of Bacillus diversity and the limitations of the assays and phenotypes that are used to differentiate species in this genus. Further work is necessary to understand whether these strains are opportunistic pathogens or just contaminates. [ABSTRACT FROM AUTHOR]