학술논문
Update on pathogenesis of the bleeding joint: an interplay between inflammatory and degenerative pathways.
Document Type
Article
Author
Source
Subject
*JOINT diseases
*HEMOPHILIA
*LYMPHOCYTES
*INFLAMMATION
*CYTOKINES
*SYNOVIAL fluid
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*
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Language
ISSN
1351-8216
Abstract
The article discusses recent developments in the pathogenesis of blood-induced joint damage in case of haemophilic arthropathy. It is stated that infiltration of the synovial tissue with lymphocytes leads to an inflammatory reaction, resulting in cartilage damage. Recently, it has been demonstrated that induced joint bleeds in haemophilic mice resulted in an increase of pro- inflammatory cytokines in the synovial fluid.