학술논문
SARS-CoV-2 Lineage P.4 Detection in Southeast Brazil: A Retrospective Genomic and Clinical Overview.
Document Type
Article
Author
Poleti, Mirele Daiana; Lesbon, Jéssika Cristina Chagas; de Mattos Oliveira, Elisângela Chicaroni; Patané, José Salvatore Leister; Clemente, Luan Gaspar; Viala, Vincent Louis; Ribeiro, Gabriela; Pinheiro, Jéssica Fernanda Perissato; Giovanetti, Marta; Alcantara, Luiz Carlos Junior; de Lima, Loyze Paola Oliveira; Martins, Antonio Jorge; dos Santos Barros, Claudia Renata; Marqueze, Elaine Cristina; de Souza Todão Bernardino, Jardelina; Moretti, Debora Botequio; Brassaloti, Ricardo Augusto; de Lello Rocha Campos Cassano, Raquel; Mariani, Pilar Drummond Sampaio Corrêa; Slavov, Svetoslav Nanev
Source
Subject
*SARS-CoV-2
*DNA sequencing
*PUBLIC health
*GENETIC mutation
*DISEASE prevalence
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Language
ISSN
2673-8112
Abstract
São Paulo state has been the epicenter of the Coronavirus Disease 2019 (COVID-19) in Brazil, ranking first by state with over six million reported cases. In February 2021, the P.4 lineage was reported in 21 cities across the state by public health authorities due to the L452R mutation. Here, by analyzing 17,304 genome sequences of SARS-CoV-2 sampled between February and August of 2021 in 476 distinct cities in São Paulo, we assess the transmission dynamics of the P.4 lineage and other SARS-CoV-2 variants that were, at the time of the study, co-circulating in the state. Additionally, clinical parameters from the city of Araras, São Paulo (N = 251) were considered to estimate the potential risk and mortality rate associated with the P.4 lineage since its higher prevalence was observed in that city. Our data suggest a low frequency (0.55%) of the P.4 lineage across the state, with the gamma variant being the dominant form in all regions (90%) at that time. Furthermore, no evidence of increased transmissibility and disease severity related to the P.4 lineage was observed. The displacement through the time of different lineages in São Paulo highlights how challenging genomic surveillance appears to track the emergence of new SARS-CoV-2 lineages, which could better guide the implementation of control measures. [ABSTRACT FROM AUTHOR]