학술논문

Evaluation of coagulation parameters in dogs with gallbladder mucoceles.
Document Type
Article
Source
Journal of Veterinary Internal Medicine. Jul2021, Vol. 35 Issue 4, p1763-1772. 10p.
Subject
*SYSTEMIC inflammatory response syndrome
*BLOOD coagulation factor VIII
*COAGULATION
*GALLBLADDER
*DOGS
*BLOOD coagulation factors
Language
ISSN
0891-6640
Abstract
Background: Gallbladder mucocele (GBM) is a common biliary disorder in dogs. Limited information is available on the coagulation status of dogs with GBM. Hypothesis/Objectives: To determine patterns of coagulation alterations in dogs with GBM and correlate them with clinicopathologic abnormalities and ultrasonographic findings of disease severity. Animals: Twenty‐three dogs with GBM identified on ultrasound examination were prospectively enrolled. Methods: At the time of GBM identification, blood and urine were collected for CBC, serum biochemical panel, urinalysis, prothrombin time, activated partial thromboplastin time (aPTT), factor VIII, protein C (PC), von Willebrand's factor (vWF), antithrombin activity, fibrinogen, D‐dimers, and thromboelastrography (TEG). Gallbladder mucoceles were classified into ultrasound types 1 to 5. Medical records were reviewed for clinical presentation, underlying conditions and to determine if systemic inflammatory response syndrome (SIRS) was present. Results: Based on TEG parameters, maximal amplitude, and G, 19/23 (83%) of dogs with GBM had evaluations consistent with hypercoagulability. On plasma‐based coagulation testing, dogs with GBM had increased total PC activity (20/23, 87%), fibrinogen (9/23, 39%), platelet count (9/23, 39%), and D‐dimers (6/15, 40%) as well as prolongations in aPTT (9/22, 41%) and low vWF activity (5/21, 24%). No correlation was found between TEG G value and any coagulation or clinical pathology variables, ultrasound stage of GBM or disease severity as assessed by the presence of SIRS. Conclusions and Clinical Importance: Dogs with ultrasonographically identified GBM have changes in whole blood kaolin‐activated TEG supporting a hypercoagulable state although traditional plasma‐based coagulation testing suggests that a complex state of hemostasis exists. [ABSTRACT FROM AUTHOR]