부산대학교 도서관

Introduction The use of liver retransplantation (Re LT) for hepatitis C virus ( HCV) recurrence is controversial because of subsequent viral recurrence after Re LT. Methods Case-control analysis between patients undergoing Re LT for HCV reinfection between 1993 and 2012 (Re LT group: 26 patients) and patients undergoing liver transplantation ( LT) for HCV infection immediately before and after each Re LT ( LT group: 52 patients). Results Re LT group had worse hepatocellular function, higher preoperative viral load, higher transfusion requirements, and increased number of postoperative complications than LT group. Re LT patients showed a trend toward worse graft survival compared with LT (five-yr graft survival: 42.3% vs. 64.3%, p = 0.145), but the rate of severe HCV recurrence and infection-free survival ( IFS) was similar. The use of donors older than 60 yr led to a lower IFS and graft survival in both groups. Early severe HCV infection rate was similar in both groups, but it affected prognosis in Re LT more markedly than in LT (three-yr graft survival: 0% vs. 66.7%, p = 0.003). Conclusions Re LT for HCV reinfection has acceptable results when strict selection policies of donor and recipient are applied. However, early severe recurrence more markedly impairs prognosis in Re LT patients than in LT. [ABSTRACT FROM AUTHOR]