학술논문
Timing of start of systemic treatment in patients with asymptomatic metastasized pancreatic cancer (TIMEPAN): a protocol of a multicenter prospective patient preference non-randomized trial.
Document Type
Letter to the Editor
Author
Augustinus, Simone; Broekman, Thijmen; Creemers, Geert-Jan; Daamen, Lois A.; van Dieren, Susan; de Groot, Jan-Willem B.; Cirkel, Geert A.; Homs, Marjolein Y. V.; van Laarhoven, Hanneke W. M.; van Leeuwen, Lobke; Los, Maartje; Luelmo, Saskia A. C.; van Oijen, Martijn G. H.; Spierings, Leontine E. A. M.; de Vos-Geelen, Judith; Besselink, Marc G.; Wilmink, Johanna W.
Source
Subject
*PANCREATIC tumors
*RESEARCH
*METASTASIS
*MANN Whitney U Test
*REGRESSION analysis
*T-test (Statistics)
*QUESTIONNAIRES
*CHI-squared test
*DESCRIPTIVE statistics
*KAPLAN-Meier estimator
*QUALITY of life
*LONGITUDINAL method
*OVERALL survival
*PROPORTIONAL hazards models
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Language
ISSN
0284-186X
Abstract
The article focuses on a multicenter prospective patient preference trial named "Timing of start of systemic treatment in patients with asymptomatic metastasized pancreatic cancer (TIMEPAN)." Topics include the lack of evidence on treatment initiation timing, the potential benefits and risks of immediate versus delayed systemic treatment, and the trial's methodology, including patient eligibility criteria and study design alteration due to recruitment challenges.