학술논문
Aging-associated deficit in CCR7 is linked to worsened glymphatic function, cognition, neuroinflammation, and β-amyloid pathology.
Document Type
Article
Author
Source
Subject
*AMYLOID plaque
*MICROGLIA
*NEUROINFLAMMATION
*COGNITION
*REGULATORY T cells
*CAPILLARIES
*MYELOID cells
*KILLER cells
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Language
ISSN
2375-2548
Abstract
The article presents a study examining how Aging-associated deficit in C-C chemokine receptor type 7 (CCR7) is linked to worsened glymphatic function, cognition, neuroinflammation, and beta-amyloid pathology. It mentions Aging leads to a progressive deterioration of meningeal lymphatics and peripheral immunity, which may accelerate cognitive decline. It found that an age-related reduction in CCR7 dependent egress of immune cells through the lymphatic vasculature mediates aging.