학술논문
Muscle mass as a modifier of stress response in acute ischemic stroke patients.
Document Type
Article
Author
Arsava, Ethem Murat; Gungor, Levent; Sirin, Hadiye; Sorgun, Mine Hayriye; Aykac, Ozlem; Batur Caglayan, Hale Zeynep; Kozak, Hasan Huseyin; Ozturk, Serefnur; Topcuoglu, Mehmet Akif; Akpinar, Erhan; Argın, Mehmet; Aydingoz, Ustun; Bugrul, Ahmet; Eryildiz, Ezgi Sezer; Guler, Ayse; Kesen, Sevcihan; Nazliel, Bijen; Ozdemir, Atilla Ozcan; Peynir, Sehriban; Polat, Ahmet Veysel
Source
Subject
Language
ISSN
2045-2322
Abstract
Stroke triggers a systemic inflammatory response over the ensuing days after the cerebral insult. The age and comorbidities of the stroke population make them a vulnerable population for low muscle mass and sarcopenia, the latter being another clinical condition that is closely associated with inflammation, as shown by increased levels of pro-inflammatory biomarkers, including neutrophil-to-lymphocyte ratio (NLR). In this study, we evaluated the relationship between post-stroke NLR changes and muscle mass in a prospective cohort of acute ischemic stroke patients (n = 102) enrolled in the Muscle Assessment in Stroke Study Turkey (MASS-TR). Admission lumbar computed tomography images were used to determine the cross-sectional muscle area of skeletal muscles at L3 vertebra level and calculate the skeletal muscle index (SMI). The median (IQR) SMI was 44.7 (39.1–52.5) cm2/m2, and the NLR at admission and follow-up were 4.2 (3.0–10.5) and 9.4 (5.7–16.2), respectively. While there was no relationship between SMI and admission NLR, a significant inverse correlation was observed between SMI and follow-up NLR (r = − 0.26; P = 0.007). Lower SMI remained significantly associated (P = 0.036) with higher follow-up NLR levels in multivariate analysis. Our findings highlight the importance of muscle mass as a novel factor related to the level of post-stroke stress response. [ABSTRACT FROM AUTHOR]