학술논문
WT1-specific CTL cells of recipient origin may exist in the peripheral blood of patients achieving full donor chimerism soon after nonmyeloablative transplantation.
Document Type
Article
Author
Source
Subject
*STEM cell transplantation
*CELL-mediated cytotoxicity
*CHIMERISM
*T cells
*ORGAN donors
*TRANSPLANTATION of organs, tissues, etc.
*BLOOD
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Language
ISSN
0902-0063
Abstract
Wei L, Zuo H, Sun X, Liu T, Guo M, Liu G, Sun Q, Qiao J, Wang D, Yu C, Hu K, Dong Z, Ai H. WT1-specific CTL cells of recipient origin may exist in the peripheral blood of patients achieving full donor chimerism soon after nonmyeloablative transplantation. Clin Transplant 2011: 25: 689-696. © 2011 John Wiley & Sons A/S. Abstract: This study was performed to assay whether leukemia-associated antigen (LAA)-specific CTLs of recipient origin existed in the blood of patients who achieved full donor chimerism (FDC) soon after nonmyeloablative transplantation (NST). In 15 patients who received haplo-identical NST, WT1+CD8+CTLs were detected with WT1/HLA-A*0201 pentamer, and the donor-recipient chimerism levels were analyzed by three methods. Results showed that WT1+CD8+CTLs could be detected in patients with HLA-A*0201 expressing only in recipient, and cells of recipient origin existed in the blood of patients who achieved FDC, which suggested that LAA-specific CTLs of recipient origin may exist in patients achieving FDC soon after NST. [ABSTRACT FROM AUTHOR]