학술논문
Effect of olive oil phenolic compounds on the expression of blood pressure-related genes in healthy individuals.
Document Type
Article
Author
Source
Subject
*ANTIOXIDANTS
*BLOOD pressure
*STATISTICAL correlation
*CROSSOVER trials
*DIET
*GENE expression
*HIGH density lipoproteins
*LOW density lipoproteins
*OLIVE oil
*PHENOLS
*RESEARCH funding
*T-test (Statistics)
*VEGETABLE oils
*RENIN-angiotensin system
*BLIND experiment
*MONONUCLEAR leukocytes
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Language
ISSN
1436-6207
Abstract
Purpose: To investigate whether the ingestion of olive oil having different phenolic contents influences the expression of blood pressure-related genes, involved in the renin-angiotensin-aldosterone system, in healthy humans. Methods: A randomized, double-blind, crossover human trial with 18 healthy subjects, who ingested 25 mL/day of olive oils (1) high (366 mg/kg, HPC) and (2) low (2.7 mg/kg, LPC) in phenolic compounds for 3 weeks, preceded by 2-week washout periods. Determination of selected blood pressure-related gene expression in peripheral blood mononuclear cells (PBMNC) by qPCR, blood pressure and systemic biomarkers. Results: HPC decreased systolic blood pressure compared to pre-intervention values and to LPC, and maintained diastolic blood pressure values compared to LPC. HPC decreased ACE and NR1H2 gene expressions compared with pre-intervention values, and IL8RA gene expression compared with LPC. Conclusions: The introduction to the diet of an extra-virgin olive oil rich in phenolic compounds modulates the expression of some of the genes related to the renin-angiotensin-aldosterone system. These changes could underlie the decrease in systolic blood pressure observed. [ABSTRACT FROM AUTHOR]