학술논문
Ischaemic postconditioning protects isolated mouse hearts against ischaemia/reperfusion injury via sphingosine kinase isoform-1 activation.
Document Type
Article
Source
Subject
*ISCHEMIA
*BLOOD circulation disorders
*SPHINGOSINE
*REPERFUSION injury
*BIOGENIC amines
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Language
ISSN
0008-6363
Abstract
Aims: Sphingosine-1-phosphate (S1P) plays a vital role in cytoskeletal rearrangement, development, and apoptosis. Sphingosine kinase-1 (SphK1), the key enzyme catalyzing the formation of S1P, mediates ischaemic preconditioning. Ischaemic postconditioning (POST) has been shown to protect hearts against ischaemia/reperfusion injury (IR). To date, no studies have examined the role of SphK1 in POST. [ABSTRACT FROM PUBLISHER]