학술논문
Targeted chemical profiling for p-HAP glycosides by using molecular networking and comparative analysis of their contents between Artemisia japonica and Artemisia capillaris.
Document Type
Article
Source
Subject
*CHINESE medicine
*ANTACIDS
*RESEARCH funding
*HERBAL medicine
*ANTINEOPLASTIC agents
*FLAVONOIDS
*PHYTOCHEMICALS
*QUANTITATIVE research
*DESCRIPTIVE statistics
*MEDICINAL plants
*GLYCOSIDES
*MOLECULAR structure
*MASS spectrometry
*MOLECULAR biology
*COMPARATIVE studies
*DATA analysis software
*ANTIMALARIALS
*CHROMATOGRAPHIC analysis
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Language
ISSN
1028-6020
Abstract
A total of 65 phenolic acid compounds were annotated or identified by UHPLC-MS/MS method, among them, 17 p-HAP (p-hydroxyacetophenone) glycosides were firstly targeted profiled based on molecular networking. Their characteristic product ions of MS/MS spectra were found and examined on the guideline of targeted isolation. As a result, a new p-HAP glycoside was thus obtained and determined as 2′-O-caffeoyl-p-HAP-4-O-β-D-glucopyranoside (33) based on 1D and 2D NMR data. Besides, multicomponents quantitative analysis indicated the distinct regional variability in chemicals distribution of A. japonica, and meanwhile, the contents of p-HAP glycosides from A. japonica were higher than those in A. capillaris as a whole, which further suggested the potential medicinal value of A. japonica. [ABSTRACT FROM AUTHOR]