학술논문
Cortical activation for adolescent-onset minor depression and major depressive disorder: an fNIRS study.
Document Type
Article
Author
Source
Subject
*DIAGNOSIS of mental depression
*NEUROLOGIC examination
*RESEARCH funding
*PREFRONTAL cortex
*NEAR infrared spectroscopy
*ANXIETY
*TEMPORAL lobe
*HAMILTON Depression Inventory
*PSYCHOLOGICAL tests
*COMPARATIVE studies
*MENTAL depression
*ADOLESCENCE
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Language
ISSN
1744-859X
Abstract
Background: While depression is increasing worldwide, some patients are diagnosed as having Major Depressive Disorder (MDD), but others are diagnosed with minor depression, however, the potential neuro mechanism is unknown. Methods: Sixty-two patients with minor depression, 44 adolescents with MDD and 54 healthy adolescents participated in this study. Functional near-infrared spectroscopy (fNIRS), both HAMD and HAMA data were collected from all of the participants. Results: The result indicates the pervasively decreased activation of BA, 11, 21, 45 and 46 were observed in the MDD group and reduced activation of BA 45 was observed in the minor depression group. However, cortical activation was not observed between the minor depression or MDD groups. Cortical activation was also not correlated with the depressive/anxious score in the minor and MDD groups separately. Conclusions: Cortical activation was pervasively decreased in the MDD group and slightly reduced in the minor depression group, which may be a potential neural mechanism. As reduced cortical activation in minor depression, interventions in the early stages of minor depression may help slow or even modify the development of the illness. [ABSTRACT FROM AUTHOR]