부산대학교 도서관

Background: Chemokine ligand 13 (CXCL13) is believed to play a role in the recruitment of B cells in the central nervous system during neuroinflammation. Neurosyphilis is a group of clinical syndromes of the central nervous system caused by Treponema pallidum ( T. pallidum) infection. The relationship between CXCL13 and neurosyphilis still needs further study. In our study, CSF and serum CXCL13 concentrations were detected among 40 neurosyphilis patients, 31 syphilis/non-neurosyphilis patients, 26 non-syphilis/other central nervous system diseases patients. Serum CXCL13 concentrations were detected in 49 healthy persons. All enrolled persons were HIV-negative. Receiver operating characteristic (ROC) analysis was performed to determine the threshold value that could distinguish neurosyphilis from syphilis. Results: We found that the CSF CXCL13 concentrations and CXCL13 quotient (Q) were significantly increased in neurosyphilis patients compared to syphilis/non-neurosyphilis (χ = 21.802, P < 0.001) and non-syphilis patients (χ = 7.677, P = 0.002). ROC curve analyses revealed that CSF CXCL13 concentrations and Q could serve as valuable biomarkers for differentiating neurosyphilis from non-neurosyphilis/syphilis. Conclusions: The CSF CXCL13 and Q could serve as valuable biomarkers for differentiating neurosyphilis from non-neurosyphilis/syphilis in HIV-negative patients. [ABSTRACT FROM AUTHOR]