부산대학교 도서관

Graphical abstract Highlights • Siloxane-phosophocholines spontaneously self-assemble into unilamellar vesicles. • Self-assembly is driven by both the hydrophobic effect and oleophobic effect. • Siloxane-phosphocholine membranes are relatively fluid. Abstract We have synthesized six new hybrid siloxane phosphocholines (SiPCs) and examined their self-assembly behaviour in aqueous dispersions. Employing small angle X-ray scattering we have characterized SiPC bilayers. SiPCs exhibit differential self-assembly behaviour that results from the interplay between the siloxane fatty acid in the sn -2 position and the differing chain length fatty acids in the sn-1 position. SiPCs that possess a fatty acid chain of a C 8 –C 14 chain length in the sn -1 position form unilamellar vesicles. Extending the fatty acid chain length to C 16 and C 18 allows for the formation of both unilamellar and multilamellar vesicles. We propose that the preferential formation of unilamellar vesicles is the result of an enhanced hydrophobic effect imparted by siloxane chains at the termini of lipid tails. [ABSTRACT FROM AUTHOR]