학술논문
Dynamics of Cell Generation and Turnover in the Human Heart.
Document Type
Article
Author
Bergmann, Olaf; Zdunek, Sofia; Felker, Anastasia; Salehpour, Mehran; Alkass, Kanar; Bernard, Samuel; Sjostrom, Staffan L.; Szewczykowska, Mirosława; Jackowska, Teresa; dos Remedios, Cris; Malm, Torsten; Andrä, Michaela; Jashari, Ramadan; Nyengaard, Jens R.; Possnert, Göran; Jovinge, Stefan; Druid, Henrik; Frisén, Jonas
Source
Subject
*HEART development
*CELL growth
*MESENCHYMAL stem cells
*MYOCARDIUM physiology
*ENDOTHELIAL cells
*HEART cells
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Language
ISSN
0092-8674
Abstract
Summary The contribution of cell generation to physiological heart growth and maintenance in humans has been difficult to establish and has remained controversial. We report that the full complement of cardiomyocytes is established perinataly and remains stable over the human lifespan, whereas the numbers of both endothelial and mesenchymal cells increase substantially from birth to early adulthood. Analysis of the integration of nuclear bomb test-derived 14 C revealed a high turnover rate of endothelial cells throughout life (>15% per year) and more limited renewal of mesenchymal cells (<4% per year in adulthood). Cardiomyocyte exchange is highest in early childhood and decreases gradually throughout life to <1% per year in adulthood, with similar turnover rates in the major subdivisions of the myocardium. We provide an integrated model of cell generation and turnover in the human heart. Video Abstract [ABSTRACT FROM AUTHOR]