학술논문
Preparation and spatial structure of methyl ether of 7β-methyl-D-homo-6-oxaestra-1,3,5(10),8(9)-tetraen-17a-one.
Document Type
Article
Author
Source
Subject
*METHYL ether
*NUCLEAR magnetic resonance spectroscopy
*ESTROGEN receptors
*ESTROGEN
*LIGANDS (Chemistry)
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Language
ISSN
1070-3632
Abstract
Procedure of preparation of 7β-methyl-D-homo-6-oxa-1,3,5(10),8,(9)-estratetraen-17a-one methyl ether has been developed; the product conformation in the solution has been studied by NMR spectroscopy. Comparison of the experimental data with simulation of similar compounds docking into the ligand-binding pocket of the estrogens α-receptor has suggested that such steroids are promising for preparation of biologically active substances whose action would not be mediated by the estrogens receptors. [ABSTRACT FROM AUTHOR]