학술논문
Effects of Hypocalcemic Vitamin D Analogs in the Expression of DNA Damage Induced in Minilungs from hESCs: Implications for Lung Fibrosis.
Document Type
Article
Source
Subject
*VITAMIN D
*PULMONARY fibrosis
*DNA damage
*HUMAN embryonic stem cells
*DOUBLE-strand DNA breaks
*VITAMIN D receptors
*CELLULAR aging
*DNA repair
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Language
ISSN
1661-6596
Abstract
In our previous work, we evaluated the therapeutic effects of 1α,25-Dihydroxyvitamin D3, the biologically active form of vitamin D, in the context of bleomycin-induced lung fibrosis. Contrary to the expected, vitamin D supplementation increased the DNA damage expression and cellular senescence in alveolar epithelial type II cells and aggravated the overall lung pathology induced in mice by bleomycin. These effects were probably due to an alteration in the cellular DNA double-strand breaks' repair capability. In the present work, we have evaluated the effects of two hypocalcemic vitamin D analogs (calcipotriol and paricalcitol) in the expression of DNA damage in the context of minilungs derived from human embryonic stem cells and in the cell line A549. [ABSTRACT FROM AUTHOR]