학술논문
Transferrin C2 variant does confer a risk for Alzheimer's disease in caucasians.
Document Type
Article
Source
Subject
*ALZHEIMER'S disease
*CAUCASIAN race
*TRANSFERRIN
*BLOOD proteins
*GENES
*DISEASES
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Language
ISSN
1387-2877
Abstract
Several gene mutations are associated with an increased risk of Alzheimer's disease. Previous studies reported higher transferrin C2 allele frequencies in Alzheimer's disease compared with normal controls. However, potential interactions between transferrin C2 and APOE (ℇ4), have not been extensively investigated and have been the subject of controversial reports from several laboratories. We have carried out a case-control study on the association between Alzheimer's disease and transferrin C2 and APOE ℇ4 alleles. ℇ4 allele was associated with a four fold increase in the risk of disease, and transferrin C2 allele was significantly associated with Alzheimer's disease only in ℇ4 negative subjects. These results suggest that apoE and transferrin may be part of a complex mechanism in the pathogenesis of Alzheimer's disease. [ABSTRACT FROM AUTHOR]