학술논문

[1,5]-Hydride Shift Triggered N -Dealkylative Cyclization into 2-Oxo-1,2,3,4-tetrahydroquinoline-3-carboxylates via Boronate Complexes.
Document Type
Article
Source
Molecules. Aug2022, Vol. 27 Issue 16, p5270-5270. 9p.
Subject
*RING formation (Chemistry)
*AMIDES
*MOLECULES
*HETEROCYCLIC compounds
*NITROGEN
Language
ISSN
1420-3049
Abstract
A new simple one-pot two-step protocol for the synthesis of 2-oxo-1,2,3,4-tetrahydroquinoline-3-carboxylate from 2-(2-(benzylamino)benzylidene)malonate under the action of BF3·Et2O was developed. It was shown that the reaction proceeds through the formation of a stable iminium intermediate containing a difluoroboryl bridge in the dicarbonyl fragment of the molecule. [ABSTRACT FROM AUTHOR]