학술논문
Neuroprotective and Antiamnesic Effect of Erythropoietin Derivatives after Experimental Ischemic Injury of Cerebral Cortex.
Document Type
Article
Author
Source
Subject
*PREFRONTAL cortex
*PROTEINS
*ERYTHROPOIETIN
*ISCHEMIA
*CEREBRAL cortex
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Language
ISSN
0007-4888
Abstract
Using the model of bilateral photothrombosis of the blood vessels in the prefrontal cortex we have shown that new hybrid proteins derived from recombinant human erythropoietin, carbamylated EPO-Fc and EPO-TR fusion proteins, injected intraperitoneally 1 h after ischemic injury contribute to restoration of passive avoidance response formed before photothrombotic injury and reduction in the volume of the ischemic focus. These data attest to nootropic and neuroprotective activities of these hybrid proteins. Carbamylated glycopeptide derivative ЕPO-TR exhibited prolonged neuroprotective properties. [ABSTRACT FROM AUTHOR]