학술논문
Immune Modulation of HIV-1 Reservoir Size in Early-Treated Neonates.
Document Type
Article
Author
Source
Subject
*IMMUNOREGULATION
*HIV
*NEWBORN infants
*CLINICAL trial registries
*IMMUNOLOGIC memory
*PSYCHONEUROIMMUNOLOGY
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Language
ISSN
0022-1899
Abstract
Immune mechanisms that modulate human immunodeficiency virus-1 (HIV-1) reservoir size in neonates are poorly understood. Using samples from neonates who initiated antiretroviral therapy shortly after birth, we demonstrate that interleukin-8–secreting CD4 T cells, which are selectively expanded in early infancy, are more resistant to HIV-1 infection and inversely correlated with the frequency of intact proviruses at birth. Moreover, newborns with HIV-1 infection displayed a distinct B-cell profile at birth, with reduction of memory B cells and expansion of plasmablasts and transitional B cells; however, B-cell immune perturbations were unrelated to HIV-1 reservoir size and normalized after initiation of antiretroviral therapy. Clinical Trials Registration. NCT02369406. [ABSTRACT FROM AUTHOR]