학술논문
Safety and effcacy of remimazolam tosilate for sedation during combined spinal-epidural anesthesia for orthopedic procedures: a randomized controlled trial.
Document Type
Article
Author
Source
Subject
*BENZODIAZEPINES
*DRUG efficacy
*ANESTHESIA
*EPIDURAL anesthesia
*ORTHOPEDIC surgery
*VITAL signs
*PATIENT satisfaction
*RANDOMIZED controlled trials
*IMIDAZOLES
*DESCRIPTIVE statistics
*RESEARCH funding
*SPINAL anesthesia
*STATISTICAL sampling
*DRUG side effects
*TRANQUILIZING drugs
*PATIENT safety
*EVALUATION
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Language
ISSN
1471-2253
Abstract
Objective: The objective of this study was to assess the efficacy and safety of Remimazolam in the context of combined spinal-epidural anesthesia for sedation during orthopedic surgery. Methods: This randomized controlled trial enrolled patients scheduled for orthopedic surgery under combined spinal-epidural anesthesia (N = 80), who were randomly allocated to receive either dexmedetomidine (Group-D) or remimazolam (Group-R). The target sedation range aimed for a Ramsay score of 2–5 or a BIS value of 60–80 to evaluate the effectiveness and safety of remimazolam during sedation. Results: The time taken to achieve the desired level of sedation was significantly shorter in the remimazolam group compared to the dexmedetomidine group (3.69 ± 0.75 vs. 9.59 ± 1.03; P < 0.0001). Patients in the remimazolam group exhibited quicker recovery, fewer intraoperative adverse events, more consistent vital signs, and greater satisfaction at various time points throughout the surgery. Conclusion: This preliminary study demonstrates that remimazolam tosilate serves as a safe and effective sedative for orthopedic surgery performed under combined spinal-epidural anesthesia, in comparison with dexmedetomidine. [ABSTRACT FROM AUTHOR]