부산대학교 도서관

Basal cell carcinomas (BCC) have been suggested to invade along the "path of least resistance", that is, invade vertically through skin to underlying bone or cartilage, then spread laterally along periosteum or perichondrium rather than through them.[1] Given anatomic sites have varying composition of skin and underlying tissue, BCC invasion pattern may vary by site.[2] Surgical margins when excising BCCs account for subclinical tumour extension (SCTE).[3] Current recommended margins range from 3 to 15 mm, depending on patient and tumour characteristics.[4] A 4-mm margin achieves 85%-96% clearance, suggesting that 4%-15% of BCCs have SCTE >4 mm.[[5]] Studies have examined the relationship between anatomic sites and SCTE, but data to guide margins for specific anatomic sites remain sparse.[[2]] This study sought to determine if anatomic sites of BCCs can be predictors for SCTE. Patients' sex, and BCCs on EFPs, mouth, nose and chin were not predictive of SCTE. [Extracted from the article]