학술논문
The Lack of Alterations in Metabolites in the Medial Prefrontal Cortex and Amygdala, but Their Associations with Autistic Traits, Empathy, and Personality Traits in Adults with Autism Spectrum Disorder: A Preliminary Study.
Document Type
Article
Author
Source
Subject
*PREFRONTAL cortex
*PERSONALITY
*BRAIN
*EMPATHY
*METABOLOMICS
*PROTON magnetic resonance spectroscopy
*COGNITION
*CHOLINE
*CREATINE
*AUTISM
*QUESTIONNAIRES
*DESCRIPTIVE statistics
*AMYGDALOID body
*GLUTAMINE
*PHOSPHOLIPIDS
*ADULTS
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Language
ISSN
0162-3257
Abstract
Proton magnetic resonance spectroscopy (1H-MRS) has shown inconsistent alterations in brain metabolites of adults with autism spectrum disorder (ASD). We investigated brain metabolites in the medial prefrontal cortex and amygdala of 24 drug-naive adults with ASD and no intellectual disability and 24 non-ASD control subjects, using 3 T 1H-MRS. Adults with ASD showed no significant differences from control in glutamate, glutamate plus glutamine, N-acetylaspartate, glycerophosphorylcholine plus phosphorylcholine, creatine plus phosphocreatine, or myo-inositol in either region. However, ASD subjects did show significant correlations of localized brain metabolites with autistic traits, empathy deficits, and personality traits using the Autism-Spectrum Quotient, Questionnaire of Cognitive and Affective Empathy, Interpersonal Reactivity Index, and NEO Personality Inventory-Revised. These findings should be taken as preliminary or exploratory. [ABSTRACT FROM AUTHOR]