학술논문
Amyloidßinduces neuronal cell death through ROS-mediated ASK1 activation.
Document Type
Article
Author
Source
Subject
*AMYLOID
*CELL death
*NEUROTOXICOLOGY
*ORGANELLES
*ALZHEIMER'S disease
*NEURONS
*
*
*
*
*
Language
ISSN
1350-9047
Abstract
Amyloidß(Aß) is a main component of senile plaques in Alzheimer's disease and induces neuronal cell death. Reactive oxygen species (ROS), nitric oxide and endoplasmic reticulum (ER) stress have been implicated in Aß-induced neurotoxicity. We have reported that apoptosis signal-regulating kinase 1 (ASK1) is required for ROS- and ER stress-induced JNK activation and apoptosis. Here we show the involvement of ASK1 in Aß-induced neuronal cell death. Aßactivated ASK1 mainly through production of ROS but not through ER stress in cultured neuronal cells. Importantly, ASK1-/- neurons were defective in Aß-induced JNK activation and cell death. These results indicate that ROS-mediated ASK1 activation is a key mechanism for Aß-induced neurotoxicity, which plays a central role in Alzheimer's disease.Cell Death and Differentiation (2005) 12, 19-24. doi:10.1038/sj.cdd.4401528 [ABSTRACT FROM AUTHOR]