학술논문
Nearly Complete Response of Brain Metastases from HER2 Overexpressing Breast Cancer with Lapatinib and Capecitabine after Whole Brain Irradiation.
Document Type
Article
Source
Subject
*BRAIN metastasis
*BREAST cancer
*HER2 gene
*LAPATINIB
*DEOXYCYTIDINE
*GENE expression
*PHYSIOLOGICAL effects of radiation
*THERAPEUTICS
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Language
ISSN
2090-6706
Abstract
Trastuzumab treatment does not prevent intracranial seeding and is largely ineffective for established central nervous system metastasis in HER2 overexpressing breast cancer patients. Combination therapy of lapatinib and capecitabine may be an effective treatment option for brainmetastasis of HER2-positive breast cancer. We report a patient with breast cancer overexpressing HER-2 where brain metastases were successfully treated with radiation and a combination of lapatinib and capecitabine. [ABSTRACT FROM AUTHOR]