부산대학교 도서관

This article discusses the role of dipeptidyl peptidase-4 (DPP4) in senescent vascular smooth muscle cells (VSMCs) and atherosclerosis. The study found that DPP4 expression was higher in senescent VSMCs and correlated with the expression of senescence-associated secretory phenotype (SASP) factors. Inhibition of DPP4 promoted cell death of senescent VSMCs and improved plaque stability in an atherosclerotic mouse model. The study also identified two clusters of DPP4-expressing senescent VSMCs and found that DPP4 inhibition could suppress the expression of SASP factors in these clusters. However, it is important to note that while animal studies have shown cardiovascular benefits associated with DPP4 inhibitors, human trials have not shown the same results. Further research is needed to understand the differences between animal and human studies and to explore the potential of DPP4 inhibition as a treatment for atherosclerosis. [Extracted from the article]