학술논문
Stereodivergent Synthesis of 3‐Hydroxyprolines and 3‐Hydroxypipecolic Acids via Ketoreductase‐Catalyzed Dynamic Kinetic Reduction.
Document Type
Article
Source
Subject
*AMINO acids
*ISOMERS
*ACIDS
*ENZYMES
*BIOCATALYSIS
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Language
ISSN
1615-4150
Abstract
We report a practical enzymatic approach for the stereoselective synthesis of hydroxylated cyclic amino acids. Using ketoreductases, cyclic ketoesters are converted with high diastereo‐ and enantioselectivity to all isomers of 3‐hydroxyproline and 3‐hydroxypipecolic acid via a dynamic kinetic reduction reaction. This work highlights the ability of enzymes to provide solutions to challenges in stereoselective synthesis. [ABSTRACT FROM AUTHOR]