학술논문
Shock-and-kill versus block-and-lock: Targeting the fluctuating and heterogeneous HIV-1 gene expression.
Document Type
Article
Author
Source
Subject
*HIV
*GENE expression
*HEMOPHILIACS
*AIDS patients
*PROTEIN kinase C
*JAK-STAT pathway
*CELL determination
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Language
ISSN
0027-8424
Abstract
Later,Daretal.(9)further measured the amplitude of HIV-1 gene expression fluctuations (coefficient of variation [CV]) and the duration of HIV-1 gene expression (time) to quantify the level of HIV-1 gene expression fluctuations in individual cells. Current strategies for HIV-1 eradication requireeither inducing HIV-1 expression to expose latently infected cells for immune clearance [known as the "shock-and-kill strategy" (1)] or silencing HIV-1 expression for a prolonged drug-freeremission[knownasthe"block-and-lockstrategy" (2)]. COMMENTARY Shock-and-killversusblock-and-lock:Targetingthe fluctuatingandheterogeneousHIV-1 geneexpression Yang-Hui Jimmy Yeh a and Ya-Chi Ho a,1 Despite effective antiretroviral therapy, HIV-1 persistence in the latent reservoir remains the major barrier to cure. [Extracted from the article]